Technology in Compression………Equal force for improving Tablet Quality


Technology in Compression………Equal force for improving Tablet Quality

 Controlling tablets’ individual weight is critical to tablet pressing. Two factors that are difficult to control, yet are fundamental to a tablet’s bioavailability and clinical effect, are tensile strength and disintegration rate. This article will examine a recent development in tablet compression that enables consistent tablet production. The article will explain how the development’s flexibility can take into account the critical factors in tablet production and improve tablet quality. Traditional tablet presses measure a tablet’s weight either by measuring its variation in tablet height at precompression or the force at main compression. These techniques, however, overlook one fundamental characteristic: tensile strength. A tablet’s tensile strength influences its bioavailability and clinical effect, which are crucial characteristics for any dosage form.

Compression to equal thickness

All rotary tablet presses on the market use the same compression principle. They compress a volume of powder, captured in a die, between two rollers using an upper and lower punch. By changing the distance between the rollers, one adjusts the force used to compress tablets. Once the distance between the rollers is set, the compression force will stay the same, thus ensuring that tablets are compressed to an equal thickness (ET). Several factors affect the precise amount of powder that is captured within each die. For example, granule size, size distribution, and variation in punch length can have an effect. In addition, an excessively high rotational speed allows the powder insufficient time to fall into the die. Variations in the amount of powder in each die result in tablets of different weights and densities, and these tablets require different forces for compression to ET.

The magnitude of the compression force affects tablet hardness and disintegration time. An increase in compression force produces an increase or decrease in disintegration time, depending on the formulation. These results show that an inconsistency in the maximum compression force can result in inconsistent tablet properties, thus affecting the efficacy of the dosage form.

Compression to equal force


Compression to equal force (EF) is a new concept that allows tablets to be compressed at the same peak compression force, independent of tablet weight. This method relies on an air compensator.

The air compensator is installed at the precompression and main compression stations. The assembly is attached to a compression roller mounted on a piston. The piston moves vertically in a cylinder filled with compressed air. The air pressure in the cylinder is preset and kept constant by a pressure-regulating valve and an expansion chamber. Because the surface of the cylinder and the air pressure are constant, the force is also constant. If the air pressure in the cylinder is such that this maximum compression force is higher than the actual compression force, the system compresses tablets to ET. On the other hand, the press can be set up so that the distance

between the two rollers and the air pressure in the air compensator make the compression roller move up at each compression. In this arrangement, all tablets are compressed at the same peak force, which is determined by air pressure and the distance between the two rollers. The thickness of individual tablets might vary as their weight varies. Variance is measured and kept within limits, however, to ensure that no problems arise during packaging. The tablet press is equipped with a linear variable displacement transducer sensor that measures compression-roller movement accurately.

Main compression

AWS is automatic weighing system. LVDT is linear variable displacement transducer. W is weight. T is thickness. H is hardness. A heavy tablet causes the compression roller to move more, a light tablet causes less movement. When compressed to EF, variations in tablet weight do not affect tensile strength. Therefore, tablets maintain a consistent clinical efficacy. The compression roller’s upward movement also has another important advantage: it increases the total compression time (i.e., the dwell time). The more the compression roller moves, the longer the dwell time.

The influence of tablet weight on density for ET and EF.

Density increases as tablet weight increases. Density decreases when tablet weight decreases. The variability of the density during compression to EF less than compression to ET.

Testing the tablets for tensile strength.

The variability in tensile strength was more significant than that of density Tablets compressed to EF showed as little variation than the tablets compressed to ET

Testing the tablets for disintegration time.

Disintegration time varied widely according to the compression technique. Tablets compressed to EF showed less variability in disintegration time than the tablets compressed to ET


Tablets compressed under equal force (EF) showed a much more consistent density, tensile strength, and disintegration rate than tablets compressed to equal thickness.