Pharma Pathway Quiz @ Pharma Talent – September, 2017


Question 1. Why Poly Alfa olefin (PAO) Used in Hepa Filter Integrity testing?

Question 2. Why Poly Alfa olefin (PAO) Replace DOP (Dioctyl Phthalate)?

Take part in Pharma Pathway Quiz. Give answer in comment box all best answer will be published on including your details.

Its Time to show your talent & share it with your friends. Give answer in comment box….


  1. Why Poly Alfa olefin (PAO) Replace DOP (Dioctyl Phthalate)?

    Answer – Poly Alpha Olefin (PAO) is used for HVAC qualification in pharmaceuticals. PAO is used as a replacement of the DOP (Dioctyl Phthalate) that was used for this purpose from a long time.

    Dioctyl Phthalate is found as a carcinogen (cause cancer) for human. Scientists were trying to find a material to replace the DOP from a long time. Finally in 2001 Japan Air Cleaning Association (JACA) published a guideline to replace the DOP with PAO. It gives the equal performance to the DOP and doesn’t have any harmful effect on health. FDA also clearly says that alternative aerosols are also acceptable but they should not promote the microbial growth in area. Therefore, it is recommended to replace the Dioctyl Phthalate with Poly Alpha Olefin (CAS #68649-12-7). The size of PAO generated aerosol ranges from 0.1 to 1.0 μm. The PAO aerosols are generated by aerosol generator and passed through the HEPA filter then the integrity is checked using a photometer. 99.97% particles having size larger than 0.3 μm should not be passed through HEPA filters.


Please enter your comment!
Please enter your name here